{"id":866,"date":"2023-01-17T14:26:54","date_gmt":"2023-01-17T14:26:54","guid":{"rendered":"https:\/\/challenge.carleton.ca\/?p=866"},"modified":"2023-11-24T09:36:00","modified_gmt":"2023-11-24T14:36:00","slug":"chronic-pain-research-safe-treatments","status":"publish","type":"post","link":"https:\/\/challenge.carleton.ca\/chronic-pain-research-safe-treatments\/","title":{"rendered":"Targeting Chronic Pain"},"content":{"rendered":"
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One in four people around the world experience chronic pain, outnumbering everybody who suffers from diabetes, heart disease and cancer combined. The overall economic impact of this condition \u2014 defined as pain that lasts for longer than three months, sometimes for no obvious reason \u2014 is estimated at more than $1 trillion USD every year.Yet chronic pain is often considered a quality-of-life concern, not a medical issue, and the majority of patients are not satisfied with the care or therapies they receive.<\/p>\n

Carleton University neuroscience researcher Michael Hildebrand<\/a> has been exploring the causes of chronic pain<\/a> for more than 15 years<\/a>. A new project he’s helming \u2014 in collaboration with Eli Lilly and Company<\/a> and The Ottawa Hospital<\/a>, among others \u2014 could lead to a better understanding of what’s happening in the spinal cord to perpetuate this pain and how to develop drugs to treat it.<\/p>\n

\"A
Neuroscience researcher Michael Hildebrand (Justin Tang)<\/figcaption><\/figure>\n

“This is a huge crisis because we’re dealing with debilitating pain as well as high health care costs and lost productivity,” says Hildebrand. “People may seem fine because they don’t always have outward signs, but it really impacts their ability to function.<\/p>\n

“We really need to move the needle on pain research,\u00a0and it’s an exciting time because we’re mobilizing to address this challenge.”<\/p>\n

Although the brain processes pain signals\u00a0and helps keep you alive by telling you something’s wrong,\u00a0these sensory impulses are first organized in and travel through the spinal cord. For some people, pain ramps up when it shouldn’t \u2014 after an injury has healed, for instance.<\/p>\n

Hildebrand believes we can treat pain more effectively by studying the spinal cord and chemically targeting areas where signals are relayed and amplified needlessly.<\/p>\n

\"A
Neurosurgeon Dr. Eve Tsai (Justin Tang)<\/figcaption><\/figure>\n

He and his students conduct experiments using spinal cord tissue from rats and human organ donors, the latter acquired through their unique partnership with neurosurgeon Dr. Eve Tsai<\/a> at The Ottawa Hospital. They record electrical signals travelling between neurons and study the molecules that control the delivery of pain signals to the brain.<\/p>\n

In a paper published earlier this year, their research showed, for the first time, that neurons in the spinal cords of men and women process pain signals differently<\/a> \u2014\u00a0a discovery that could have implications for future drug development.<\/p>\n

The Root Causes of Chronic Pain<\/h2>\n

Hildebrand and Annemarie Dedek<\/a>, <\/strong>a Mitacs<\/a> Industrial Postdoctoral Fellow at Carleton, are now working with scientists at Eli Lilly to further this research. They’re using cutting-edge high-definition multi-electrode arrays to enhance their understanding of the mechanisms of pain with the goal of developing new human tissue preclinical screening tests for pain therapies.<\/p>\n

“Our focus is investigating the underlying physiology of the human spinal cord,” says Hildebrand.<\/p><\/blockquote>\n

“A key piece of that puzzle that’s missing is figuring out what’s happening to spinal cord circuitry when you activate these pain pathways or when you block them with treatments. This project will help us identify specific molecules and receptors that are potential drug targets.”<\/p>\n

\"A
Mitacs Industrial Postdoctoral Fellow Annemarie Dedek conducting research (Justin Tang)<\/figcaption><\/figure>\n

Using traditional electrical recording technology, researchers could only study what’s happening inside tissue samples one cell at a time. The multi-electrode arrays in Hildebrand’s lab at The Ottawa Hospital \u2014\u00a0tiny chips, about six millimetres by six millimetres, containing around 4,000 electrodes \u2014\u00a0can record the activity of hundreds of neurons at the same time.<\/p>\n

“The cells in the spinal cord slices that we use are still communicating and firing,” explains Dedek, who handles the bulk of the hands-on work and relies on computer science specialists at Carleton to figure out how to store and manage the incredibly high volume of data.<\/p>\n

“I can put a slice on a multi-electrode array and record activity from the entire circuit. That’s really powerful, because it lets us look at how cells are working in tandem and see circuit-level processes that could be involved in chronic pain.<\/p>\n

“Once we understand this circuitry better,” she adds, “this technique could potentially be used to target some of the pathways that we’re studying to disrupt pain signals.”<\/p>\n

The Chronic Pain Connection<\/h2>\n

Eli Lilly approached Hildebrand after seeing Dedek give a talk at a conference.<\/p>\n

“Although the pharmaceutical industry has a greater number of resources than our academic colleagues, we don’t always have the ability to perform the exact experiments needed to test a hypothesis,” says Jeff Krajewski, an executive director of pain biology with the company.<\/p>\n

“Advances in identifying novel biological mechanisms are typically developed by academic labs<\/a>. Michael has been a major contributor to chronic pain research throughout his career. His interests aligned perfectly with ours: understanding the spinal mechanisms that underly chronic pain to aid the development of better therapies.”<\/p>\n

\"Three<\/p>\n

“We want to move toward treatments, but I can’t do all of that in my lab,” says Hildebrand.<\/p>\n

“That’s why this is such a natural partnership \u2014\u00a0Eli Lilly can use the same approaches we’re using to test how specific drugs affect spinal cord circuitry.”<\/p><\/blockquote>\n

“What keeps me going,” adds Dedek, “is the hope that we’ll have a future where chronic pain is better managed through safe, effective treatments.”<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

One in four people around the world experience chronic pain, outnumbering everybody who suffers from diabetes, heart disease and cancer combined. The overall economic impact of this condition \u2014 defined as pain that lasts for longer than three months, sometimes for no obvious reason \u2014 is estimated at more than $1 trillion USD every year.Yet […]<\/p>\n","protected":false},"author":6,"featured_media":875,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[2],"tags":[10],"yoast_head":"\nCarleton Research Partnership Aims to Alleviate Chronic Pain<\/title>\n<meta name=\"description\" content=\"Carleton University neuroscience researcher Michael Hildebrand has been exploring the causes of chronic pain for more than 15 years.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/challenge.carleton.ca\/chronic-pain-research-safe-treatments\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta 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